As an essential mineral for optimal health, magnesium is involved in many major metabolic processes, playing a crucial role in over 300 enzyme reactions operating throughout the day. Magnesium deficiency – caused by inadequate nutritional amounts in our diets – could lead to a wide range of health conditions.
With a greater need for increased minerals, Natroceutics Magnesium Complex is developed to help support healthy levels of magnesium and overcome the limitations of conventional supplementation through a complex which includes liposomal magnesium, magnesium citrate and a complete spectrum of trace minerals.
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]]>Natroceutics Magnesium Complex offers a superior solution to magnesium supplementation by combining magnesium glycinate with a liposomal delivery technology. The liposomal magnesium delivery system enhances absorption and bioavailability, ensuring that optimal magnesium intake is achieved. These bioavailable forms of magnesium promote restful sleep, reduce muscle cramps, and alleviate stress by supporting the nervous system. Additionally, its gentle formulation is ideal for individuals with sensitive stomachs, making it a perfectchoice for daily use.
Recognizing the growing demand for essential mineralswhether you’re seeking to support athletic recovery, manage stress levels, or improve your overall wellness, Natroceutics Magnesium Complex has been formulated to supplement optimal magnesium levels.
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]]>MetaRelax® Daily include Vitamins B1 & B5 to support your stress response, and Vitamins B1, B2, B3 & B5 to support energy levels.
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]]>You're not alone if you experience things like muscle cramps or twitching, poor sleep, stress and overwhelm - all of which can affect your day-to-day but more so, your ability for a good night's rest.
Magnesium Restore contains magnesium bisglycinate, which is celebrated for its superior bioavailability while being gentle on the tummy. We've also included the well-researched ingredient L-carnitine to further support energy production and fat metabolism.
We like to think of magnesium as the 'mother mineral' as it nourishes and supports your body to ensure everything is ticking along nicely and at the right pace. It plays a key role in nurturing our nervous system and stabilising our mood, so you can see why magnesium is incredibly important when it comes to how we feel on a daily basis. Try it to feel the difference.
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Description:
Magnesium is an essential mineral that acts as regulating cofactor in over 300 enzymatic reactions, affecting 80% of the body’s metabolic functions including energy synthesis, brain, bone health and heart and skeletal muscle function. Endogenous magnesium stores are primarily (99%) located in bone, muscles and soft tissues and intracellularly (in either ionised form, bound to proteins, molecules or ATP), while 1% occurs in serum (in the biologically active free-ionised form, bound to protein or anions) and red blood cells. Magnesium homeostasis is regulated by the intestines (absorption), bones (storage) and kidneys (urinary excretion). Following magnesium ingestion, intestinal absorption occurs within an hour, and following reabsorption by the kidneys is transported to the liver and subsequently circulates systemically in the blood before renal excretion. However, the amount of magnesium that is absorbed (and renally reabsorbed) is highly variable due to the influence of many factors, significantly endogenous magnesium status – low levels result in higher absorption while high levels induce lower absorption rates (up to 80% vs 30-50%, respectively). Other factors that influence magnesium absorption include chronic insufficient intake of magnesium or absorption cofactors (selenium, B6 and D), excessive phytate, saturated fat, fibre, alcohol, calcium, phosphorus, sodium, caffeine, alcohol, excessive or insufficient protein intake, age, stress, hormones (elevated thyroid hormones, oestrogen), medications, gastrointestinal dysfunction, diabetes, excessive lactation, heat and prolonged exercise. Consequently, it is estimated that at least half of the average Western population do not meet the daily recommended magnesium intake levels (which aim to prevent frank rather than subclinical deficiencies), while 10-30% have a subclinical magnesium deficiency. In addition, magnesium deficiency prevalence is also attributed to reduced fruit and vegetable magnesium concentrations, over-consumption of refined grains and processed foods, inadequate intake of magnesium-rich foods (leafy greens, nuts and whole grains), the high amount of magnesium lost during food preparation and processing and the increased consumption of purified drinking water.
It is also likely to be influenced by the challenges associated with accurately diagnosing magnesium deficiency due to serum levels (comprising 1% of total body magnesium) not being an accurate indicator of magnesium status, as well as the types of symptoms and health effects associated with subclinical magnesium deficiency. Such symptoms include impaired appetite, nausea, vomiting, fatigue, weakness, numbness, tingling, muscle contractions, cramps, seizures, sudden behaviour or personality changes and irregular heartbeat. Taken together, maximising the therapeutic potential of magnesium requires these many factors to be considered, and when supplementation is indicated, the use of magnesium sources with enhanced efficacy and biological activity.
Magnesium chelates
Along with the many factors discussed, the bioavailability and efficacy of magnesium supplementation is determined by dose frequency and load. It is also significantly influenced by the certain chemical properties of the chelated ligand, including its solubility and capacity to bind to magnesium’s active sites (the latter being associated with reduced magnesium hydration and laxative potential). The higher solubility and active-site binding capacity of organic and amino acid-based ligands contribute significantly to their optimal bioavailability. The chelates used in Tri-Mag Supreme™, amino acid chelate, orotate and glycerophosphate, have each been demonstrated to have optimal bioavailability and capacity to support endogenous magnesium levels/concentrations.
Bone health
The importance of magnesium for supporting bone health is emphasised by the high proportion of the body’s total magnesium stored in bones (60-70%). The mechanisms by which magnesium maintains healthy bones is multifaceted and includes increasing bone crystal formation, size and brittleness via binding to the hydroxyapatite crystal surface, promoting osteoblast synthesis and osteoclastic bone resorption (the latter by increasing pro-inflammatory cytokine secretion) and supporting vitamin D activation, which influences bone growth and maintenance.
Muscle health
The second highest concentration of endogenous magnesium body stores is in skeletal muscle tissues (27%). Like its role in bone tissue, magnesium is involved in a number of functional processes required to maintain muscle health. These mechanisms include supporting healthy protein synthesis and turnover balance, energy metabolism (as a cofactor for adenosine triphosphate) and maintaining normal muscle contraction, relaxation and neuromuscular function (as a Ca2+ antagonist).
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Magnesium is one of the most ubiquitous and essential minerals in the body. It is a critical nutrient in almost every cellular metabolic and biological process, with enzyme databases listing over 600 enzymes that use magnesium as a co-factor and a further 200 being directly activated by magnesium. As a structural component of the hydroxyapatite mineral matrix of bone, a natural calcium channel blocker, a required element for electrolyte balance and proper functioning of sodium-potassium pumps, magnesium plays a crucial role in supporting physical strength and mobility, muscle contraction, neurological health and cardiac function. Magnesium’s role as an enzyme cofactor for processes that generate ATP underlies its importance in energy production and metabolic processes. Protein synthesis (DNA and RNA), carbohydrate metabolism and neurotransmission are also fundamental metabolic processes that are reliant upon adequate magnesium status.
Magnesium is a critical regulator of the activity rate of the Sodium-Potassium ATPase pump (Na+, K+- ATPase pump) which is required for removal of sodium from inside the cell in exchange for potassium.6 This makes Magnesium vital for maintaining the electrical potential of skeletal muscles and nerves, and for neurotransmission across neuromuscular junctions. Magnesium deficiency can affect pump activity leading to increases in intracellular sodium, potassium and calcium. Calcium homeostasis (in part reliant on magnesium driven calcium efflux) is vital for the health of the cardiovascular system as an imbalance can contribute to alterations in blood vessel function (vasospasm and smooth muscle function) and heart rhythm. Magnesium is intimately involved in both contraction and relaxation phases of muscle movement. Right from the start, magnesium is involved the production of energy that fuels muscle function by being involved in oxygen utilisation, the production of energy (ATP and phosphocreatine) and the balance of electrolytes (particularly sodium, calcium and potassium) which is critical for the maintenance of electrical potentials that drive muscle activity. Magnesium is a critical co-factor in acetylcholine-receptor binding which triggers the initial electrical potential – the maintenance of which is influenced by magnesium (via ATPase pumps). Magnesium then regulates troponin expression and stabilises actin by creating an ATP-magnesium-actin bond without which, cross bridge formation does not occur. ATP (synthesised and then coupled with magnesium) then fuels the contraction phase. The relaxation phase is also mediated by magnesium. The rate of cross bridge disengagement is influenced by magnesium, as is the rate of calcium removal from the cell via calcium pumping mechanisms and competitive binding.
Magnesium is involved in the production of energy in several ways. Firstly, it is a co-factor in ATP synthesis and regeneration, and then a co-factor in every other process in which ATP is transferred and utilised. It is also involved in the maintenance of red blood cell embranes thereby supporting oxygen transport, the oxidation of pyruvate and subsequent creation of acetyl CoA, adequate functioning of mitochondrial enzyme processes and the metabolic breakdown of carbohydrates and fatty acids.
Magnesium plays a role in insulin signalling, insulin receptor kinase phosphorylation and the post receptional activity of insulin. It is involved in glycogen breakdown, affecting the activity of phosphorylase b kinase which in-turn releases glucose-1-phosphate for use. Magnesium also directly influences the activity of the GLUT4 receptor, allowing glucose entrance into the cell, and is a co-factor in every enzymatic reaction involved in glycolysis. Magnesium therefore plays a major role in the maintenance of blood glucose and cellular glucose metabolism.
The human body contains about 25g of magnesium and about 60% of this is held in the bone. A third of this sits on the surface, ready to replenish extracellular magnesium levels when they run low. The rest is tightly bound in hydroxyapatite crystals. Magnesium is required for the activation of Vitamin D which then assists with calcium absorption and metabolism. It also plays a key role in bone strength, remodelling and conservation. It is therefore extremely important for normal bone composition and structure.
Taurine is a non-essential sulphated amino acid that shows similar biological activity to magnesium. Taurine works alongside magnesium to stabilise electrically active cell membranes in skeletal and cardiac muscle and modulate calcium movement in and out of cells. This has a protective effect in the cardiovascular system by supporting healthy heart function (including heartbeat and cardiac output). It also limits neurotransmitter release resulting in an inhibition of neuronal excitement. Taurine may also support muscle function and enhance muscle performance by alleviating muscle soreness (through antioxidant mechanisms), modulating calcium activity, improving ATP efficiency in the mitochondria, supporting energy production via the glycolytic pathway, improving anaerobic capacity and reducing lactate accumulation in skeletal muscle.
Nicotinamide riboside is a biological precursor of Nicotinamide adenine dinucleotide (NAD+) – a vital intermediate in several metabolic processes. NAD+ has been shown to be an important factor in healthy ageing, potentially through its antioxidant and protective effects. The systems that seem to benefit the most from increases in NAD+ levels after NR supplementation are the musculoskeletal, cardiovascular and nervous systems.
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]]>A quality combination of easily absorbable forms of magnesium, activated B vitamins, including pyridoxal 5-phosphate, riboflavin sodium phosphate and folinic acid, along with amino acids, trace minerals and mitochondrial nutrients.
Orthoplex White MagOpticell offers a unique formula to help support the cardiovascular and nervous systems, along with muscle health and energy production.
Flavour: Tropical fruit punch
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]]>Is a highly bioavailable magnesium citrate formulation specifically designed for practitioners who require a brand-protected and potent magnesium in clinical practice. Proudly Australian made, CitraMag 400 delivers highly soluble magnesium citrate in a 3:2 ratio, comprising of three magnesium molecules per two citrate molecules. Developed in convenient patient-friendly sachets, CitraMag 400 meets Bio Concept’s exceptional quality and purity standards.
✓ Brand protected† magnesium
✓ High potency dose
✓ Convenient sachets
✓ 3:2 magnesium to citrate ratio
✓ Xylitol free
✓ Formulated and made in Australia
Flavour: Orange
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]]>Provides a highly affordable and exceptional quality magnesium that conforms to standards set by the United States Pharmacopoeia- National Formulary (USP-NF). USP-NF sets rigorous standards for ingredient identity, strength, quality and purity. CitraMag is specifically formulated to remove both common excipients and accessory vitamins and minerals, delivering 150mg of pure elemental magnesium with minimal excipients in vegan-friendly Vcaps®.
This product has been batch tested and certified by HASTA for over 250 banned WADA prohibited substances. HASTA is the Australian sports supplement drug testing specialist, a division of Racing Analytical Services Limited (RASL), Australia's largest independent sports drug testing laboratory.
✓ Bioavailable magnesium citrate
✓ Ultra-low excipient formulation
✓ Magnesium conforms to United States Pharmacopoeia - National Formulary
Contains magnesium which:
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