Iron is an essential mineral functioning mainly in the transport and storage of oxygen throughout the body. Around 2-4gm of iron exists in the body, the majority in haemoglobin (65%), in storage in the liver and macrophages (20%), and in storage in myoglobin (10%). The remainder resides functionally in enzyme complexes.
Iron is found in dietary sources in both heme and non-heme forms. Heme iron exists as a complex with protoporphyrin and is available in animal products such as red meat, poultry and seafood. Non-heme iron is found in both animal and plant sources including green leafy vegetables, legumes and seeds, and is available as free or weakly bound iron. Non-heme iron has an affinity for binding complexes such as phytates or polyphenols. It is, therefore, less bioavailable than heme iron.
Iron is found largely in the haemoglobin protein of erythrocytes which functions as a carrier of oxygen throughout the system. As it is a crucial constituent of haemoglobin, iron is essential not only for its production but also for optimal erythropoiesis.
Iron also functions as an iron-sulphur complex in enzymes involved in the electron transport chain and in the Krebs cycle, enabling optimal enzyme function and mitochondrial respiration. Iron, therefore, plays an essential role in energy production.
Iron is enzymatically involved in DNA synthesis making it a vital nutrient for cell growth and division. One of the major functions affected by this action is immune cell production, particularly of the T-lymphocytes.
Iron bisglycinate is an iron chelate that contains around 20% iron. It is water-soluble and largely resistant to acidic fluctuations between pH 2-6. This retains the compound’s solubility and protects it from dietary inhibitors such as phytates and polyphenols, ensuring high bioavailability of the compound.
(in the form of ascorbic acid) is a nutrient that, when taken in combination, can improve the solubility and therefore bioavailability of non-heme iron by up to 39%.
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]]>Orthoplex FemmeBiotic™ Clinical is a high strength probiotic featuring Lactobacillus rhamnosus GR-1™ and Lactobacillus reuteri RC-14™. It is formulated to help support and maintain healthy vaginal microflora and pH.
Providing multiple benefits, FemmeBiotic™ Clinical relieves vaginal discomfort, helps reduce mild vaginal itch and temporarily relieve excessive vaginal discharge. Combining three strains of vaginal origin and one originally isolated from a healthy female urethra, the formula also contains Lactobacillus acidophilus LA-5® which supports vaginal health and general health and wellbeing.
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]]>MetaRelax® Daily include Vitamins B1 & B5 to support your stress response, and Vitamins B1, B2, B3 & B5 to support energy levels.
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]]>Is formulated for busy individuals seeking enhanced energy and cognitive performance. Whether you're juggling work, family, or navigating the hormonal shifts of perimenopause and menopause, this formula offers targeted support to help you stay sharp and energised.
Menopause can bring a range of physical and cognitive changes, including low energy, brain fog, and difficulty concentrating. NaturoElite Memory & Energy Support is designed to address these challenges and help you feel more like yourself again—energised, focused, and resilient.
At the heart of this formulation are three clinically trialled and patented ingredients, complimented by Siberian ginseng, a herb traditionally used in Western herbal medicine to help the body adapt to stress and combat fatigue.
This targeted cognitive support formulation contains BacoMind®, a patented and standardised Bacopa monnieri extract which has been shown in clinical studies to improve working memory, short term verbal memory, retention and recall.
Also formulated with Ginkgo biloba as GinkgoSelect® for enhanced attention span and cognitive performance support.
It also features rhodiola as Rhodiolife®, the only sustainable rhodiola in the world, sourced from Siberia. Prescribed by herbalists for mental and emotional stress, rhodiola has been extensively clinically trialled. It is traditionally used in Western herbal medicine to improve physical and cognitive performance especially when under stress and support healthy emotional and mood balance.
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]]>Whether it's racing thoughts, waking up at odd hours, or simply feeling too wired to relax, there are lots of reasons why sleep is a challenge for many of us.
BePure Sleep & Mood combines therapeutic doses of Saffron and Magnesium to support you in not just falling asleep, but also your overall mental health and mood.
Formulated with Magnesium Bisglycinate to support calming your nervous system whilst being gentle on the gut, and high-strength Saffron Extract to support mood, relaxation, sleep quality and duration - so you can wake up feeling truly refreshed.
Suitable to take alongside other medications used for sleep support.
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]]>DIM works to support balance for skin-related hormones, and excess oil production that can lead to breakouts. MSM provides support to calm and soothe irritated skin, while Zinc supports skin healing and immune function for overall skin health.
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]]>Women have increased nutritional requirements during pregnancy - not just for folate and iodine but for the complete range of micronutrients we find in our food. BePure Mum's One contains the most bioavailable and high-strength versions of each vitamin and mineral to better support mums on their pregnancy journey and help prevent post-natal depletion.
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]]>Is a synergistic formula of 5-hydroxytryptophan (100 mg) and vitamin B6 (20 mg) per serving for supporting overall neurotransmitter metabolism by providing precursors of serotonin. 5-HTP readily enters the blood–brain barrier; however, conversion into serotonin requires the cofactor vitamin B6, which is included in this formula. 5-HTP Supreme may be used during the day to support a healthy mood and normal appetite, or it may be used at bedtime to support sleep.
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Zinc is a vital trace nutrient that displays activity in every human cell. The body contains around 2g zinc, 55-60% of which can be found in skeletal muscle, 25-30% in bone and the remaining distributed throughout other bodily fluids and tissues.
Zinc belongs to the class of type 2 nutrients, which are considered to be the building blocks of all cells. The synthesis of any new tissue requires type 2 nutrients, and zinc’s main biological functions are, therefore, catalytic, structural, or regulatory in nature.
The human body holds around 2-3g of zinc, which is distributed throughout the body. Intracellular levels are tightly controlled. An estimated 0.1% of zinc is found in serum, 60% is stored in skeletal muscle, 30% in bone and 5% in the skin. Zinc is also distributed in small amounts among other tissues, including the brain, kidneys, liver, and heart.
Zinc metalloenzymes are the most abundant of all trace mineral-dependent enzymes in the body, and as a result, zinc is involved in many cellular reactions required for the normal biological activity of the immune system, skin and bone.
Being innately involved in the normal development and function of all cells, Zinc is vital for the optimal functioning of the immune system. Zinc presides over the effective commission of both innate and adaptive immunity, assisting with the health and functioning of neutrophils, monocytes and NK cells, as well as the development of T & B-lymphocytes, macrophages and NK cells, as well as the generation of acquisitional immunity. Zinc’s involvement in immune processes is also intricately tied to inflammation and wound healing.
The skin contains around 5% of the total body store of zinc (50-70μg/g dry weight), mostly sequestered in the epidermis. Zinc is essential for producing zinc finger motifs and biomembranes in DNA transcription factors and is therefore required for building all new body tissues.
It is required for the proliferation and differentiation of keratinocytes, stratum corneum formation and metabolism and epidermal tight junction function. Any imbalance of epidermal zinc stores affects enzyme and transcriptional activity and zinc finger protein function, ultimately resulting in epidermal barrier dysfunction and sub-optimal skin health.
Zinc deficiency can also hamper wound healing, and supplementation and topical application can be used to restore zinc levels, enhance re-epithelialisation and collagen synthesis, reduce inflammation, and enable optimal wound healing.
Zinc is present in high concentrations in the retina and choroid of the eye. It functions as both a tissue protectant having antioxidant activity in the retina and retinal pigment epithelium (RPE) and a visual function aid in that it modulates synaptic transmission, modifies plasma membranes in the photoreceptors and regulates the light-rhodopsin reaction. It is also involved in the enzymatic conversion of retinol to retinal, which is a critical step in the visual cycle.
Around 30% of the total body zinc stored resides in skeletal tissue; adequate dietary intake is vital to ensure bone quality. Zinc is a vital cofactor for several enzymes involved in producing bone matrix components and oversees the cycle of bone deposition and resorption. It is also complexed with fluoride in hydroxyapatite crystals.
The steroid receptor superfamily of transcription factors is zinc-dependent. These zinc finger transcription factors arbitrate the physiological response to numerous hormonal and metabolic signals. Inadequate zinc intake has been linked to low serum concentrations of several hormones, including testosterone.
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Description:
Magnesium is an essential mineral that acts as regulating cofactor in over 300 enzymatic reactions, affecting 80% of the body’s metabolic functions including energy synthesis, brain, bone health and heart and skeletal muscle function. Endogenous magnesium stores are primarily (99%) located in bone, muscles and soft tissues and intracellularly (in either ionised form, bound to proteins, molecules or ATP), while 1% occurs in serum (in the biologically active free-ionised form, bound to protein or anions) and red blood cells. Magnesium homeostasis is regulated by the intestines (absorption), bones (storage) and kidneys (urinary excretion). Following magnesium ingestion, intestinal absorption occurs within an hour, and following reabsorption by the kidneys is transported to the liver and subsequently circulates systemically in the blood before renal excretion. However, the amount of magnesium that is absorbed (and renally reabsorbed) is highly variable due to the influence of many factors, significantly endogenous magnesium status – low levels result in higher absorption while high levels induce lower absorption rates (up to 80% vs 30-50%, respectively). Other factors that influence magnesium absorption include chronic insufficient intake of magnesium or absorption cofactors (selenium, B6 and D), excessive phytate, saturated fat, fibre, alcohol, calcium, phosphorus, sodium, caffeine, alcohol, excessive or insufficient protein intake, age, stress, hormones (elevated thyroid hormones, oestrogen), medications, gastrointestinal dysfunction, diabetes, excessive lactation, heat and prolonged exercise. Consequently, it is estimated that at least half of the average Western population do not meet the daily recommended magnesium intake levels (which aim to prevent frank rather than subclinical deficiencies), while 10-30% have a subclinical magnesium deficiency. In addition, magnesium deficiency prevalence is also attributed to reduced fruit and vegetable magnesium concentrations, over-consumption of refined grains and processed foods, inadequate intake of magnesium-rich foods (leafy greens, nuts and whole grains), the high amount of magnesium lost during food preparation and processing and the increased consumption of purified drinking water.
It is also likely to be influenced by the challenges associated with accurately diagnosing magnesium deficiency due to serum levels (comprising 1% of total body magnesium) not being an accurate indicator of magnesium status, as well as the types of symptoms and health effects associated with subclinical magnesium deficiency. Such symptoms include impaired appetite, nausea, vomiting, fatigue, weakness, numbness, tingling, muscle contractions, cramps, seizures, sudden behaviour or personality changes and irregular heartbeat. Taken together, maximising the therapeutic potential of magnesium requires these many factors to be considered, and when supplementation is indicated, the use of magnesium sources with enhanced efficacy and biological activity.
Magnesium chelates
Along with the many factors discussed, the bioavailability and efficacy of magnesium supplementation is determined by dose frequency and load. It is also significantly influenced by the certain chemical properties of the chelated ligand, including its solubility and capacity to bind to magnesium’s active sites (the latter being associated with reduced magnesium hydration and laxative potential). The higher solubility and active-site binding capacity of organic and amino acid-based ligands contribute significantly to their optimal bioavailability. The chelates used in Tri-Mag Supreme™, amino acid chelate, orotate and glycerophosphate, have each been demonstrated to have optimal bioavailability and capacity to support endogenous magnesium levels/concentrations.
Bone health
The importance of magnesium for supporting bone health is emphasised by the high proportion of the body’s total magnesium stored in bones (60-70%). The mechanisms by which magnesium maintains healthy bones is multifaceted and includes increasing bone crystal formation, size and brittleness via binding to the hydroxyapatite crystal surface, promoting osteoblast synthesis and osteoclastic bone resorption (the latter by increasing pro-inflammatory cytokine secretion) and supporting vitamin D activation, which influences bone growth and maintenance.
Muscle health
The second highest concentration of endogenous magnesium body stores is in skeletal muscle tissues (27%). Like its role in bone tissue, magnesium is involved in a number of functional processes required to maintain muscle health. These mechanisms include supporting healthy protein synthesis and turnover balance, energy metabolism (as a cofactor for adenosine triphosphate) and maintaining normal muscle contraction, relaxation and neuromuscular function (as a Ca2+ antagonist).
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